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Various

"Scientific American Supplement, No. 787, January 31, 1891"


It is just in looking at such changes that the effect of the remedy
appears to consist. It contains a certain quantity of necrotizing
substance, a correspondingly large dose of which injures certain
tissue elements even in a healthy person, and perhaps the white blood
corpuscles or adjacent cells, thereby producing fever and a
complication of symptoms, whereas with tuberculous patients a much
smaller quantity suffices to induce at certain places, namely, where
tubercle bacilli are vegetating and have already impregnated the
adjacent region with the same necrotizing matter, more or less
extensive necrosis of the cells, with the phenomena in the whole
organism which result from and are connected with it.
For the present, at least, it is impossible to explain the specific
influence which the remedy, in accurately defined doses, exercises
upon tuberculous tissue, and the possibility of increasing the doses
with such remarkable rapidity, and the remedial effects which have
unquestionably been produced under not too favorable circumstances.
Of the consumptive patients whom he described as temporarily cured,
two have been returned to the Moabit Hospital for further observation.


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